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Yoshihiro Mimaki Selected Research

nobiletin

1/2018Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.
7/2016Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells.
8/2015Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).
1/2014Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.
10/2013Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.
8/2013Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.
8/2013Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.
2/2013Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
1/20136-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.
1/2013Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.
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Yoshihiro Mimaki Research Topics

Disease

11Leukemia
01/2022 - 10/2002
10Neoplasms (Cancer)
08/2020 - 02/2002
7Alzheimer Disease (Alzheimer's Disease)
01/2018 - 06/2006
5Dementia (Dementias)
01/2018 - 07/2011
4Memory Disorders (Memory Loss)
07/2016 - 09/2008
4Cognitive Dysfunction
08/2015 - 05/2007
3Carcinoma (Carcinomatosis)
11/2021 - 01/2015
3Renal Cell Carcinoma (Grawitz Tumor)
01/2018 - 01/2015
3Neuroblastoma
01/2018 - 02/2013
2Carcinogenesis
01/2018 - 01/2013
2Neurodegenerative Diseases (Neurodegenerative Disease)
08/2013 - 12/2005
2Type 2 Diabetes Mellitus (MODY)
04/2012 - 05/2005
1Liver Diseases (Liver Disease)
01/2020
1Interstitial Lung Diseases (Interstitial Lung Disease)
01/2020
1Adenocarcinoma of Lung
01/2019
1Obesity
01/2018
1Amyloid Plaque
08/2015
1Hepatocellular Carcinoma (Hepatoma)
01/2015
1Astrocytoma (Pilocytic Astrocytoma)
06/2014
1Hyperlipidemias (Hyperlipidemia)
02/2013
1Hyperglycemia
02/2013
1Glioma (Gliomas)
01/2013
1Ischemia
10/2009
1Brain Ischemia (Cerebral Ischemia)
10/2009
1Nervous System Diseases (Neurological Disorders)
05/2007
1Hypertension (High Blood Pressure)
11/2003
1Abdominal Obesity
11/2003
1Atherosclerosis
06/2003
1Inflammation (Inflammations)
06/2003
1Fibrosarcoma
02/2002

Drug/Important Bio-Agent (IBA)

18nobiletinIBA
01/2018 - 02/2002
8GlycosidesIBA
01/2022 - 10/2002
8FlavonoidsIBA
08/2015 - 02/2002
5Proteins (Proteins, Gene)FDA Link
01/2017 - 09/2008
3CardenolidesIBA
11/2021 - 02/2007
3Amyloid (Amyloid Fibrils)IBA
01/2018 - 09/2008
3flavoneIBA
07/2016 - 01/2013
3N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
08/2015 - 05/2007
3Pharmaceutical PreparationsIBA
06/2014 - 12/2005
2TriterpenesIBA
01/2022 - 09/2004
2N-(6,7-difluoroquinolonyl)ampicillinIBA
01/2018 - 01/2017
2schweinfurthin AIBA
06/2014 - 08/2011
2SaponinsIBA
08/2009 - 09/2004
2Amyloid beta-PeptidesIBA
09/2008 - 06/2006
2Etoposide (VP 16)FDA LinkGeneric
08/2007 - 06/2003
2PPAR gammaIBA
05/2005 - 11/2003
1BromidesIBA
09/2020
1bufadienolideIBA
08/2020
1Adenosine Triphosphatases (ATPase)IBA
08/2020
1pregnane glycosideIBA
01/2019
1oleananeIBA
12/2018
1daisaikotoIBA
01/2018
1Neprilysin (Neutral Endopeptidase)IBA
01/2018
1Lipase (Acid Lipase)FDA Link
01/2018
1Sirtuin 1IBA
01/2018
1Messenger RNA (mRNA)IBA
01/2017
1ElementsIBA
07/2016
1Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2015
1DigitoxigeninIBA
01/2015
1Cytochalasin BIBA
06/2014
1Cytoskeletal ProteinsIBA
06/2014
1Actins (F Actin)IBA
06/2014
1Neurofibromin 1 (Neurofibromin)IBA
06/2014
1EnzymesIBA
05/2014
1Indicators and Reagents (Reagents)IBA
08/2013
1ThioredoxinsIBA
08/2013
1Caspase 3 (Caspase-3)IBA
08/2013
1TunicamycinIBA
08/2013
1DNA (Deoxyribonucleic Acid)IBA
02/2013
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2013
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2013
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
04/2012
1Hypoglycemic Agents (Hypoglycemics)IBA
04/2012
1OSW 1IBA
08/2011
1OxysterolsIBA
08/2011
1Carrier Proteins (Binding Protein)IBA
08/2011
1cephalostatin IIBA
08/2011
1ritterazine BIBA
08/2011
1oxysterol binding proteinIBA
08/2011
1Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
10/2009
1Peptides (Polypeptides)IBA
09/2008
1glaziovianin AIBA
06/2007
1IsoflavonesIBA
06/2007
1polyglutamineIBA
12/2005
1CurcuminIBA
05/2005
1ar-turmeroneIBA
05/2005
1demethoxycurcuminIBA
05/2005
1bisdemethoxycurcuminIBA
05/2005
1Oleanolic AcidIBA
09/2004
1LigandsIBA
11/2003
1A-factor (Streptomyces)IBA
06/2003
1progelatinaseIBA
02/2002
1pro-matrix metalloproteinase 9IBA
02/2002
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
02/2002
1Tissue Inhibitor of Metalloproteinase-1IBA
02/2002
1Matrix Metalloproteinases (MMPs)IBA
02/2002
1Metalloproteases (Metalloproteinases)IBA
02/2002
1procollagenaseIBA
02/2002

Therapy/Procedure

2Kampo Medicine (Kampo)
01/2020 - 01/2018
2Therapeutics
10/2009 - 02/2002